1. Functional Assessment and Therapy Perioperative

The dysfunction of organs and systems and the functional reserve of these are important factors for perioperative evolution. The identification of these disorders and the functional reserve is essential not only for assessing the risk of perioperative morbidity and mortality, but also as part of the preoperative preparation, since many disorders can receive therapeutic approach to improve the organic functional reserve such as respiratory therapy , cardiovascular rehabilitation and motor, among others. In this line of research are conducted mainly clinical studies, although there are also experimental protocols.


  1. Nutrition and Metabolism in Surgery

Eating disorders and metabolic consequences, particularly obesity, is a medical and social problem important nowadays and imposes considerable risk in the perioperative period. The treatment of morbid obesity through surgery has been successful in relation to weight loss, but still need studies to better understand not only the eating disorder, but also the consequences of treatment.

Moreover, not only the morbid obesity related operations can lead to morphological and functional and metabolic changes, but other operations and therapeutic interventions, such as those employed in the treatment of cancer, may also result in nutritional and metabolic changes.


  1. Study of Organic Response to Trauma

It is known that the response to an aggression to the tissues, organs and systems is not restricted to the primary site of aggression, whether it therapeutic or not, but it is systemic in varying degrees, and is characterized by endocrine, metabolic and immune responses. In this line of research is understood by trauma not only the effect of physical agents, including surgical trauma, but also caused by chemical and biological agents, among others. Thus, this line of research aims at a better understanding of local and systemic response triggered by damage from several attacks, including the trauma caused by therapeutic interventions. In addition to clinical studies, this line will also carry out experimental studies using morphological techniques, morphometric, histochemical and immunohistochemical to better understand the response of various tissues to the different forms of aggression.

  1. Biology of Transplantation of Organs and Tissues

Organ transplantation has been practiced by various specialties that make up the Department of Surgery and Anatomy, FMRP-USP and the study of aspects of physiology, morphology, pathophysiology, and outcomes of patients who received transplanted organs and tissues it is essential for better understanding and employment of such therapy. In addition to clinical studies, this line of research also conducts experimental studies.

  1. Study of Epilepsy Difficult to Control

The study of epilepsy refractory to medical treatment and surgical options for the treatment of the same, when the generating area of ​​abnormal electrical activity can be located, is the objective of this line of research that employs both clinical research projects as animal experimentation.

  1. Surgical Oncology Translational

We understand translational research as one that promotes multidirectional integration of basic research with research directed to the care of the patient and that population-based which aims to improve the population’s health, as proposed by Rubio et al. (Acad Med 2010 March; 85 (3):. 470-475). Although the molecular processes are the basis for development of virtually all pathological processes having different molecular mechanisms regulating key role in diseases such of microRNAs. Oncology is one of the medical specialties that has most benefited from studies involving the field of molecular biology, this field has been rapid progress in recent years, with interesting consequences for the diagnosis, treatment and monitoring of cancer patients. We also study energy, fundamental processes for the development and maintenance of tumor environment. We performed the analysis of the genome and mitochondrial function, with emphasis on energy changes that occur in different tumors. A number of enabling technologies have expanded the knowledge of how molecular biology can help in the management of cancer through clinical studies using tissue samples from invasive medical procedures or from experimental models. Moreover, with a broader Translational goal, this line of research interests also study the epidemiology and the clinical behavior of tumors compared to the different treatments and molecular markers.



  1. Ischemia and Reperfusion

In this line of research are included clinical and experimental projects that study the pathophysiology, prevention and treatment of ischemia and reperfusion syndromes in different clinical and surgical situations, such as peripheral aterias obstructions, coronary and cerebral and global cardiac ischemia during operations heart. Also of interest to this line of research the consequences of global ischemia and reperfusion of organs in transplant situations.

  1. Regeneration and Reconstruction Tissue

This line is to study therapies aimed at the structural and functional regeneration of organs and tissues such as those using microsurgery, stem cells, cell growth factors, gene therapies, biomaterials, hyperbaric oxygen, among others, by experimental and clinical studies.

  1. Vascular Function

Blood vessels, especially the endothelium and vasoactive factors, plays an important role in vascular homeostasis and in many pathological processes, local and systemic, in which surgeons have expertise. Thus, it is of capital importance the role of knowledge vascular not only in pathological and therapeutic processes in which the blood vessels are the primary seat of the disease, such as aneurysms, atherosclerosis and vascular inflammatory diseases, but also in pathological processes involving other organs and systems in which the vasculature is central role in the pathophysiology, such as sepsis, response to trauma and transplant rejection. To this line also interest the study of various therapeutic interventions used for the treatment of vascular diseases.

  1. Morphofunctional Studies in Surgery

This research aims to study the influence of morphological changes, particularly those that result in organ dysfunction, whether acquired or congenital changes, as well as the relationship of the anatomical structures with the surgical technique. Therefore, this line of research is concerned with studies involving:

– The morphological changes associated with congenital malformations, as well as the mechanisms involved in the pathogenesis of these malformations, by conducting clinical and experimental studies.

– Knowledge of the morphological and functional characteristics of acquired diseases to better understanding of the pathophysiology, not only to adapt the existing surgical approaches, but also to suggest new surgical approaches and assess the results of corrections proposed by clinical and experimental studies

– A better understanding of “surgical anatomy” aiming to propose new surgical techniques and surgical approaches.